He will hit ninth against the Seattle Mariners on Saturday afternoon.
Espinal will start at second base after a prolonged stint on the injured list due to a strained left oblique.
He was placed on the 10-day IL on Sept. 21 and was returned to the Blue Jays roster on Friday.
Whit Merrifield was moved to left field with Espinal’s return and will hit eighth.
Toronto lost Game 1 of the best-of-three series 4-0 on Friday.